Relationship between Discordance of Low-Density Lipoprotein and Non-High-Density Lipoprotein Cholesterol and Risk Stratification in Acute Myocardial Infarction

Abstract Background: Sizeable proportion of patients have discordant low-density lipoprotein cholesterol (LDL-C) and non-high density (NHDL-C). It has been shown that discordance LDL-C NHDL-C either underestimates or overestimates coronary risk. Objective: We assessed whether this an impact on GRACE TIMI risk scores in with acute myocardial infarction (AMI). Methods: retrospectively evaluated the data 198 consecutive AMI. Fasting serum lipid profiles were recorded, calculated. Patients divided into 3 groups according to percentiles: Discordant group: (n=48). scores, mortality cardiovascular events (heart failure, non-fatal angina) at sixth month compared between these three groups. Differences analyzed One-way ANOVA Kruskal-Wallis rank test, chi-square for percentages. Also, post hoc LSD Conover-Iman's non-parametric multiple comparison test used. A p value (p=0.029 0.008, respectively). Cardiovascular not different among (p=0.473 p=0.176, Conclusion: score was higher group LDL-C<NHDL-C, but there is no difference regarding concordant AMI patients.